Amlodipine Overdose

Calcium channel blocker overdose: Experience with amlodipine

Amlodipine overdose is only scarcely reported from India. We report two cases of near fatal Amlodipine overdose managed in our ICU with fluid, vasopressors, calcium infusion and Glucagon. Literature is reviewed and other treatment modalities discussed.

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Efficacy of isoproterenol for treating amlodipine overdose resulting in bradycardia

Case Amlodipine predominantly affects vascular smooth muscle cells. Amlodipine overdose usually presents with vasodilatory shock, accompanied by reflex tachycardia rather than bradycardia.An 81-year-old woman presented with impaired consciousness 8 h after ingesting 50 5-mg amlodipine tablets with suicidal intent. On admission, her blood pressure was 50/40 mmHg and her heart rate was 45 b.p.m. ...

A Case of Amlodipine Overdose: Role of High Dose Insulin Therapy

Calcium channel blockers (CCB) are a leading cause of mortality from drug overdose among cardiovascular medicine [1]. CCBs are commonly used for treating hypertension, angina, and arrhythmias. However in an overdose, this can lead to cardiogenic shock that is difficult to treat with vasopressors alone and is especially problematic for long-acting agents such as amlodipine. Insulin is widely use...

Bilateral blindness secondary to optic nerve ischemia from severe amlodipine overdose: a case report

BACKGROUND Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of consciousness. We describe a case of a calcium channel blocker overdose that led to bilateral cortical blindness, a presentation that has not previously b...